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Novel Methods for the Visualization and Analysis of Functional Maps in Cortex

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ISBN: 3827409896   ISBN: 3827409896   ISBN: 3827409896   ISBN: 3827409896 
 
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Flat Maps 19 The functional flat maps are used by mrFindBorders to identify retinotopic visual areas, i.e., only two-dimensional images have to be registered. High-dimensional volumetric warps with more degrees of freedom are not necessary. Therefore, one reason for using flat maps is the easier computation.   An important question to ask is if there is a disadvantage when using flat maps. As ex- plained in chapter 2, the cortex is a folded sheet in three-space. It consists of several layers. The number of layers varies depending on the location. For example, area V1 can be subdi- vided into 6 layers and is about 3-4 mm thick (see section 2.3). However, a two-dimensional functional image that integrates the cortical activity across the cortical layers is no disadvan- tage  since  the  inplane  resolution  is  about  2  mm  x  2  mm,  where  inplanes  are  about  3  mm apart2.  Therefore,  the  resolution  is  too  low to measure the functional signals from different cortical  layers,  and  the  activity  is  therefore  integrated  across  the  layers  even when the gray matter layers are represented in three-space. 3.7  Creating Flat Maps This section describes how flattened representations of the cortical surface are generated. This includes the MRI scanning procedures, which produce anatomical data sets, fMRI scanning for functional data, segmentation and classification of the volumetric anatomy data set, and finally   the   actual   flattening   procedure.   In   addition,   it   is   briefly   explained,   how   a   low- resolution functional data set is aligned with a high-resolution anatomical data set. 3.7.1 High-Resolution Anatomy Scan The  first  anatomical  scan  is  a  high-resolution  T1-weighted  MRI  scan.  Within  about  seven minutes, 124 sagittal slices from the whole brain are measured. Each slice has 256 pixels x 256 pixels. This scan leads to a 3-dimensional volume anatomical data set and is only done                                                 2 The values are given for a 3 T scanner; the inplane resolution for a 1.5 T scanner is about 2.8 mm x 2.8 mm.  
  
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