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Novel Methods for the Visualization and Analysis of Functional Maps in Cortex

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ISBN: 0815340788   ISBN: 0815340788   ISBN: 0815340788   ISBN: 0815340788 
 
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189 9 Summary The visual cortex, which can be found in the occipital lobe, can be subdivided into different visual areas. The visual areas are an important part of cortex organization. Among others, the areas V1, V2, and V3 are retinotopically organized, i.e., adjacent points in the visual field map onto adjacent points in the retinotopically organized visual cortex.   To improve the visualization, the cortical surface can be flattened. Functional magnetic resonance imaging data, which is recorded from the cortical gray matter while a certain visual stimulus is presented to a subject, can be displayed in two-space. Based on the resulting func- tional  flat  maps,  retinotopically  organized  visual  areas  can  be  identified.  Often  this  is  done manually. The developed tool, called mrFindBorders, uses functional flat maps to segregate retinotopic visual areas with only little user interaction. Such a semi automatic approach is not only less user-time consuming, it is also more systematic, i.e., the results do not depend as much on the performance of the user as in manual identification.   The  program  creates  labeled  atlas  images,  which  are  initially  aligned  with  their  corre- sponding measured flat maps. The atlases show expected pattern of brain activity. The align- ment can be improved by deforming the atlases. In the current implementation, the deforma- tion is defined by pixel displacement fields. Displacement values are only assigned to a subset of all pixels to reduce the degrees of freedom. This yields faster computation and smoother deformations.  The  displacement  values for the other pixels are calculated based on the dis- placement values for the subset of pixels by interpolation. Once the atlas images have been
  
The Biology of Cancer
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Molecular Biology of the Cell
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